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44(3):1146-1160
VEGFR-3 and PDGFR-β with IC50s of 0
Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents
184(11):6529-36
InChi: InChI=1S/C20H22N2O/c23-12-11-21-19-8-4-7-16-17-13-15(14-5-2-1-3-6-14)9-10-18(17)22-20(16)19/h1-3
ML-329 - CAS# 19992-50-8 Catalog No.:M6543-2 44(3):1146-1160ML 329, CAS No. 19992 50 8, is an inhibitor of the microphthalmia associated transcription factor (MITF) pathway with an IC50 value of 1. 2 M for promoter activity of the MITF target gene TRPM 1. ML 329 showed specific activity against the MITF dependent cells, primary melanocytes but no effect on the viability in A375 cells. ML 329 reduced the expression of multiple MITF target genes, including pigment related genes and the cell cycle regulator CDK2.
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